Dynamic 3d Strain Mapping of Cortical Bone Microdamage Initiation and Propagation
نویسندگان
چکیده
INTRODUCTION Vast research efforts have been undertaken in recent decades to provide insight into bone fracture mechanics, which is relevant for various metabolic bone diseases. As part of the global effort to improve current methods for fracture prediction, this study turns to the murine model of osteoporosis. Using bone samples of inbred rodents guarantees genetically controlled phenotypes, and simplified bone structure.
منابع مشابه
Similar damage initiation but different failure behavior in trabecular and cortical bone tissue.
The mechanical properties of bone tissue are reflected in its micro- and nanostructure as well as in its composition. Numerous studies have compared the elastic mechanical properties of cortical and trabecular bone tissue and concluded that cortical bone tissue is stiffer than trabecular bone tissue. This study compared the progression of microdamage leading to fracture and the related local st...
متن کاملSimilar Damage Initiation but Different Failure Behavior in Trabecular and Cortical Bone Tissue
INTRODUCTION: The mechanical function of bone tissue is reflected in its microand nanostructure as well as in its composition. Numerous studies have compared the elastic mechanical properties of cortical and trabecular bone tissue and concluded that cortical bone tissue is stiffer than trabecular bone tissue [1]. However, the progression of microdamage leading to fracture and the related local ...
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The balance between local remodeling and accumulation of trabecular bone microdamage is believed to play an important role in the maintenance of skeletal integrity. However, the local mechanical parameters associated with microdamage initiation are not well understood. Using histological damage labeling, micro-CT imaging, and image-based finite element analysis, regions of trabecular bone micro...
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In vivo microcracks in cortical bone are typically observed within more highly mineralized interstitial tissue, but postmortem investigations are inherently limited to cracks that did not lead to fracture which may be misleading with respect to understanding fracture mechanisms. We hypothesized that the one fatigue microcrack which initiates fracture is located spatially adjacent to elevated in...
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Accumulation of microdamage during fatigue can lead to increased fracture susceptibility in bone. Current techniques for imaging microdamage in bone are inherently destructive and two-dimensional. Therefore, the objective of this study was to image the accumulation of fatigue microdamage in cortical bone using micro-computed tomography (micro-CT) with a barium sulfate (BaSO(4)) contrast agent. ...
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